Agreth the Nether Spider punishes ordinary AoE teams. Her spiderlings counterattack, heal the boss, and apply unavoidable Poison. The safest solution is to cleanse often, attack Agreth with single-target skills, avoid heavy Turn Meter reduction, and deal damage through HP Burn or another controlled strategy.
Quick answer
Use one or two fast cleansers, reliable healing or revival, and champions with single-target basic attacks. Focus Agreth and leave the spiderlings alone while Counterattack is active. HP Burn—especially from Geomancer, Drexthar, or a skill that does not hit the spiderlings—provides safe boss damage. Disable unnecessary AoE attacks and large Turn Meter reductions in the AI preset.
Agreth the Nether Spider mechanics
The battle opens with Agreth summoning four spiderlings, giving them Counterattack, and launching a team attack. This places multiple Poison debuffs before your champions can establish control. The fight is therefore decided by what your team does immediately after the opening attack.
| Mechanic | What it does | How to counter it |
|---|---|---|
| Envenomed Strands | Attacks the entire team and places unavoidable 5% Poison. Agreth repeats the attack for each spiderling without an active buff. | Cleanse immediately or use enough healing to survive the next poison activation. |
| Brood Feast | Summons four spiderlings, places Counterattack on them, and triggers a team attack. Agreth opens the boss round with this skill. | Prepare a fast cleanser and avoid attacking the spiderlings while Counterattack is active. |
| Elder Lurker | Agreth counterattacks whenever her Turn Meter is reduced. Damage scales with the amount removed and ignores 100% of DEF. | Disable large Turn Meter reduction skills. Small reductions are only safe on durable champions. |
| Tide of Toxins | At the start of Agreth’s turn, all Poisons deal damage immediately. Attacking her can extend debuffs and add Poison Sensitivity. | Cleanse before her turn and avoid unnecessary attacks from already poisoned champions. |
| Spiderling counterattacks | Each counterattacking spiderling heals Agreth by 10% of her MAX HP. Their attacks also place unavoidable Poison. | Use single-target attacks on Agreth, crowd-control the spiderlings, or remove or block Counterattack before using AoE. |
| Ally Protection | When a spiderling’s Counterattack expires or is removed, it places protected Ally Protection on Agreth. | Removing Counterattack prevents healing but may slow damage on the boss. Choose one strategy and build around it. |
How to beat Nether Spider step by step
Prepare the opening cleanse
Agreth always opens with Brood Feast. Your cleanser should act soon after the opening team attack and remove the first Poison stack before Agreth activates it.
Target Agreth only
Use single-target basic attacks and select the boss manually. Disable avoidable AoE skills so the spiderlings do not counterattack and restore Agreth’s HP.
Cleanse before her turn
Do not wait for four-turn Poisons to expire. Agreth activates them at the start of her turn, so remove them while her Turn Meter is approaching full.
Apply safe damage
Single-target HP Burn, passive HP Burn, Geomancer’s reflection, Warmaster, and controlled single-target damage reduce Agreth’s HP without constantly triggering spiderlings.
Protect the cleansers
Add healing, revival, Decrease ATK, shields, and strong base HP. A second cleanser prevents the run from collapsing when one champion is delayed or killed.
Test the AI preset
Run the boss manually first. Then disable dangerous AoE and Turn Meter skills, prioritize cleanse, and confirm that every champion targets Agreth on auto.
Three reliable Nether Spider strategies
1. Ignore the spiderlings
Use only single-target attacks, cleanse the team repeatedly, and slowly burn or damage Agreth. This is usually the safest progression approach.
2. Control the spiderlings
Stun or Freeze the spiderlings before using AoE attacks. Crowd control prevents their counterattacks and stops them healing Agreth.
3. Geomancer reflection
Place Geomancer’s HP Burn on Agreth and let enemy AoE attacks trigger his passive. Heal Reduction can prevent spiderling counterattacks from restoring the boss.
Which strategy is best?
Use the single-target sustain strategy for a first clear. Move to crowd control or Geomancer only when your champions, Accuracy, Speed, and AI setup support it.
Best champions for Nether Spider
The strongest teams usually combine a cleanser who acts early, a second source of cleansing or revival, passive healing, and a damage dealer who does not force repeated spiderling counterattacks.
| Champion | Main role | Why they work | Availability |
|---|---|---|---|
| Geomancer | HP Burn Reflection | Places single-target HP Burn and reflects damage from enemy attacks back to Agreth. Excellent for a controlled boss-focused team. | Epic |
| Drexthar Bloodtwin | Passive HP Burn Tank | Can burn enemies when they hit him, generating damage without deliberately attacking the spiderlings. | Legendary |
| Mordecai | HP Burn No-hit placement | Places HP Burn without dealing a hit, avoiding immediate spiderling counterattacks. | Epic |
| Pythion | Cleanse Revive | Combines full-team cleansing, healing, damage reduction, and revival in one safe support slot. | Legendary |
| Raglin | Cleanse Revive | Fast cleansing and a short-cooldown revive make her highly effective in poison-heavy fights. | Void Legendary |
| Reliquary Tender | Cleanse Budget revive | An accessible Rare who removes all ally debuffs and provides a single-target revive. | Void Rare |
| Runekeeper Dazdurk | Cleanse Healing | Removes debuffs, heals, and boosts Turn Meter without reducing Agreth’s Turn Meter. | Epic |
| Mausoleum Mage / Skathix | Cleanse Support | Provide full-team debuff removal and useful defensive support. Set cleanse as a priority in the AI preset. | Epic |
| Doompriest | Passive cleanse Healing | Removes one debuff and heals allies each turn. Best as secondary cleansing rather than the only answer to Poison. | Epic |
| Scyl of the Drakes | Healing Revive | Passive healing and revival stabilize long runs. Her small Turn Meter reduction is safer than large reductions but still requires durability. | Login Legendary |
| Vogoth | Passive healing Debuff extension | Heals allies when taking damage and can extend useful debuffs such as HP Burn with his single-target A1. | Epic |
| Duchess Lilitu / Elva Autumnborn | Protection Revive | Premium sustain options that protect the team, heal, and recover failed runs. | Legendary |
Best Nether Spider team compositions
Drexthar + Reliquary Tender + Doompriest + Scyl + Apothecary
- Drexthar supplies passive HP Burn damage.
- Reliquary Tender is the main full-team cleanser.
- Doompriest adds passive cleansing and healing.
- Scyl provides sustain and revival.
- Apothecary increases Speed and adds direct healing.
Geomancer + Pythion + Runekeeper Dazdurk + Vogoth + Duchess
- Geomancer places HP Burn on Agreth and reflects damage.
- Pythion and Runekeeper alternate full-team cleanses.
- Vogoth supplies passive healing.
- Duchess adds protection and reliable revival.
Mordecai + Pythion + Raglin + Doompriest + single-target damage
- Mordecai places HP Burn without hitting the spiderlings.
- Pythion and Raglin handle cleansing and revival.
- Doompriest provides passive recovery between boss turns.
- The damage dealer should have a single-target A1.
Safe damage + main cleanser + backup cleanser + healer/reviver + support
- Safe damage can be single-target HP Burn, passive Burn, or direct boss damage.
- The main cleanser must act shortly after the opening attack.
- Avoid champions whose unavoidable A1 attacks every enemy.
Stats and gear priorities
Cleanser and support
- Speed: act quickly after the opening attack and cycle cleanse before the next poison activation.
- HP and DEF: survive the unavoidable Poison and direct attacks.
- Resistance: can resist Poison Sensitivity and debuff extension, but not Agreth’s unavoidable Poison.
- Useful sets: Speed, Immortal, Regeneration, Resilience, or defensive sets.
Damage and debuff champions
- Accuracy: enough for HP Burn, Heal Reduction, Decrease ATK, and other required debuffs.
- Speed: enough to refresh HP Burn consistently.
- Survival: do not build fragile glass-cannon damage dealers for the first clear.
- Masteries: Warmaster can add boss damage without requiring extra AoE attacks.
Use floor-specific stat targets
Agreth appears at different levels, affinities, and difficulties. Her Speed, Resistance, and Accuracy change between stages, so do not copy one fixed build for every floor. Check your exact stage, then make the main cleanser faster than the rest of the team and give HP Burn champions a safe Accuracy margin.
Common mistakes
Using an AoE A1
The champion attacks every spiderling on each basic turn, triggering multiple counterattacks, healing, and additional Poison.
Relying on Block Debuffs
Agreth’s core Poison cannot be blocked or resisted. Bring cleansing and healing instead of treating immunity as the main counter.
Reducing too much Turn Meter
Agreth retaliates according to the Turn Meter removed and ignores DEF. Large reductions can instantly kill the champion responsible.
Cleansing too late
Agreth activates all Poison at the start of her turn. Cleanse before her Turn Meter fills, not after the damage occurs.
Removing Counterattack without a plan
Removing the buff stops counterattacks, but the spiderlings then place protected Ally Protection on Agreth. The fight may become safer but slower.
Only bringing one slow cleanser
If the cleanser falls behind or dies, Poison quickly overwhelms the team. Add Speed, cooldown support, or a second cleansing champion.
Nether Spider rewards
Agreth drops Nether Egg materials used in the Forge for Affinitybreaker artifacts. The set adds Critical Damage and gives weak hits a chance to become critical hits, helping non-Void attackers in difficult affinity matchups. Farm the highest stage your team can clear consistently.
Frequently asked questions
What is the easiest way to beat Nether Spider?
Use a fast full-team cleanser, a backup cleanser or reviver, strong healing, and champions with single-target A1 skills. Focus Agreth and avoid attacking Counterattacking spiderlings.
Can Nether Spider’s Poison be resisted or blocked?
No. The core Poison from Agreth and her spiderlings cannot be blocked or resisted. Remove it with cleansing or survive it through strong healing.
Why does Agreth keep healing?
Each spiderling heals Agreth by 10% of her MAX HP whenever it counterattacks. Avoid AoE attacks while the spiderlings have Counterattack.
Is HP Burn good against Nether Spider?
Yes. HP Burn deals steady boss damage while reducing the number of direct attacks needed. Single-target, passive, or no-hit HP Burn is safest.
Should I kill the Nether Spiderlings?
For a safe progression team, it is usually better to ignore them and focus Agreth. Kill or attack them only after crowd control or when your strategy is designed around doing so.
Why should I avoid Turn Meter reduction?
Agreth counterattacks when her Turn Meter is reduced. The damage scales with the amount removed and ignores DEF, making large reductions dangerous.
